Cancer Research, Carlo Croce, Character Assassination, Civil Death, Clare Francis, Data Fabrication, Data Falsification, Defamation, Defamation lawsuit, First Amendment to US Constitution, Fraud, Ivan Oransky, National Institutes of Health, New York Times, NIH, NIH funding, Office of Research Integrity, Ohio State University, Paul S. Thaler, protected free speech, Research misconduct, Retraction Watch, Scientific corruption, Scientific publication

Stellar cancer researcher Carlo Croce falls from grace: hypocrisy in science

Last week The New York Times published a front-page story entitled “Years of Ethics Charges but Star Cancer Researcher Gets a Pass“.  The article grossly disparages Prof. Carlo Croce, a towering figure in cancer biology and genetics, and his home institution, The Ohio State University. It describes in some detail multiple accusations of misconduct and malfeasance that have been targeting Croce for years.

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Dr. Carlo M. Croce, Ohio State University

We are told that Croce has been dodging grave allegations that he falsified data in research supported by more than $86 million in federal grants that have been awarded to him. The investigative task of the Times reporters was greatly facilitated by the fact that the records at Ohio’s courthouses and its university system are completely open to the public. And Ohio State University, which claims it had spent more money supporting Dr. Croce’s research than it had received in grants, was apparently totally responsive to requests for records.

The big problem with all this is that to this day there is no hard evidence of misconduct implicating Croce. Ohio State had repeatedly investigated Croce and cleared him of wrongdoing every single time. How disinterested these investigations were is of course a matter of debate.

Since Dr. Carlo Croce has not been proven guilty of misconduct by the preponderance of evidence, the public does not have the right to know about these investigations and he must be presumed innocent. The integrity of Croce’s career should have been protected. The New York Times article is actionable in Court.

The most astonishing aspect of the story is that neither government agencies nor Ohio State believed Croce would be seriously investigated for misconduct, since he is one of Ohio State biggest rainmakers. This bespeaks of a system corrupt to the marrow and draws a lesson that epitomizes the level of hypocrisy that plagues the science establishment.

Of course we wonder who sent James Glanz, the Times reporter, the documents that appeared in Mr. Glanz’s email inbox, in what his collaborator Agustin Armendariz calls three big dumps. This is anyone’s guess. The Times story mentions Clare Francis, the pseudonym for an agent for the blog Retraction Watch, whose brash nauseating style is reminiscent of Ivan Oransky’s writing…

In any case, that would be discovered in Court if and when Dr. Carlo M. Croce decides to take legal action.

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Artificial windpipes, Bengt Gerdin, Clare Francis, Data Fabrication, Data Falsification, Due process, Fake Peer Review, First Amendment to US Constitution, Ivan Oransky, Karolinska Institut, Misconduct, Nature, Paolo Macchiarini, Post publication peer review, PubPeer, Retraction Watch, Science Journal, Scientific Misconduct, Scientific Research, Transplant surgery

Science properly correcting itself: The handling of alleged misconduct in claims by Paolo Macchiarini

According to a recent investigation, surgeon Paolo Macchiarini from the Karolinska Institute in Stockholm has allegedly committed scientific misconduct in his reporting of results from patient transplants of synthetic tracheas seeded with stem cells. The misconduct investigation 39-page report drafted by Bengt Gerdin, a professor at Uppsala University, reveals that in six published papers, author Paolo Macchiarini had deliberately and knowingly misrepresented or falsified medical data from recipients of the artificial tracheas. The papers allegedly boosted the results of the transplant operations making them appear far more more successful than they really were. The investigation also found that two of the papers described procedures that did not get ethical approval (Lancet 378, 1997–2004 (2011) and Biomaterials 34, 4057–4067; 2013), and that a seventh paper by Macchiarini (Nature Commun. 5, 3562; 2014) also contained fraudulent results.

The investigation launched by the Karolinska Institute began after four physicians at the institution, who were involved in the care of  Macchiarini’s transplant patients, filed formal complaints. The physicians identified themselves as Karl-Henrik Grinnemo, Matthias Corbascio, Thomas Fux and Oscar Simonson and provided medical records that are at odds with the results published by Macchiarini.

Irrespective of the validity of the misconduct findings by Bengt Gerdin, there seems to be at least one fundamental difference between this investigation and the ones prompted by the intrigues and attacks launched by PubPeer-Retraction Watch-Clare Francis contributors. In the Macchiarini case the accusers revealed their identities and proved that they were peers of the person they were accusing. In other words, they behaved as honest people would do and followed the standard course of action that science has developed to handle allegations of scientific misconduct. In addition, the procedure followed by the Karolinska Institute is the one that science has always accepted and has been in place for centuries, since the inception of scientific reporting.

By contrast, the feeders of the PubPeer-Retraction Watch-Clare Francis ring live in a world where you just sit on the outside of science and, while hiding in anonymity, take shots at those doing the actual work. Who the heck are these people at Retraction Watch and PubPeer anyway? Whose peers are they? These abominable practices must come to an end, but that will only happen when people realize that there is a fundamental difference between the way the Swedish Karolinska Institut reacted upon the allegations of four Macchiarini peers and the way amateurish editors handle the accusations by Clare Francis.

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