Adam Marcus, Agustin Armendariz, American Association of Cancer Research, Anonymous Commenter, Carlo Croce, Character Assassination, Clare Francis, Corruption, Data Fabrication, Data Falsification, Defamation, Defamation lawsuit, Fernando Pessoa (Retraction Watch), First Amendment to US Constitution, Fraud, Ivan Oransky, James Glanz, New York Times, NIH funding, Office of Research Integrity, Ohio Southern District Court, Ohio State University, Paul S. Thaler, Post Publication Peer Review Scam, PubPeer, Reporting Retractions, Reputation Damage, Retraction Watch, Scientific corruption, Scientific Integrity, Scientific Misconduct, Scientific publication

Carlo Croce sued The New York Times; he should not spare Retraction Watch

Carlo M. Croce is a towering figure in cancer genetics. His discovery of the molecular mechanisms in leukemia and other malignancies places him in the league of pioneers in the field like Janet Rowley. Croce’s peers have recognized his contributions, elected him to the US National Academy of Science in 1996 and showered him with prizes. Notwithstanding his success, concerns about the integrity of Croce’s work are surfacing and certain people seem to be now investing in his downfall. A while back, MIT Nobel laureate Philip Sharp praised him but detected some sloppiness in his work, while UC Berkeley Nobel laureate Randy Schekman claimed that as editor he became aware of certain allegations concerning Croce’s research published in the Proceedings of the National Academy of Sciences.

 

InBev+Baillet+Latour+Awards+de+la+Sante+2013+rT6H1wjTGQHl

The 2013 prize of the Artois-Baillet Latour Foundation given by HRH The Queen of Belgium to Carlo M. Croce.

Croce’s fall from grace happened when he was defamed in an article published in the New York Times on March 8 of this year. The authors of the article, James Glanz and Agustin Armendariz, tell us that Croce had been dodging misconduct allegations for decades, and that a major cover-up was put up by Ohio State University (OSU), Croce’s home institution, because he was bringing millions of dollars in grant overhead each year. Glanz and Armendariz tell us that Croce, the discoverer of cancer mechanisms that saved the lives of thousands, had been cheating all along but “was too big to make findings of misconduct on”.

The entire scientific community was in a state of shock at what seemed to be a flagrant act of defamation. In America, as in most countries under the rule of law, Croce should be presumed innocent unless proven otherwise, and his innocence should be protected at all cost, as it seemed to have been the case with OSU’s internal investigation. It came as a shock to everybody that these unresolved or closed investigations would be exposed in a major venue like the NYT, destroying in one stroke Croce’s reputation earned through decades of hard work. Yet, most of the scientific community dismissed these unproven allegations: on March 29, a few days after the defamatory article appeared in the NYT, the American Association of Cancer Research made Carlo Croce the recipient of the Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research.  Not surprisingly, this recognition emboldened Croce. Carlo Croce sued the NYT in Court for defamation a few weeks later. The particulars of the lawsuit are as follows:

Croce v. New York Times Company et al (case filed May 10, 2017)

Ohio Southern District Court
Judge: James L Graham
Referred: Terence P Kemp
Case #: 2:17-cv-00402
Nature of Suit 320 Torts – Personal Injury – Assault, Libel, & Slander
Cause 28:1332 Diversity-Libel,Assault,Slander

The lingering question is who instigated the NYT article and emboldened Glanz and Armindariz? Why would Glanz and Armendariz risk everything to go after a towering figure in cancer research, whose discoveries saved thousands of lives, with nothing more that conjectures and unproven allegations over sloppiness in reporting or conducting scientific research? Glanz and Armendariz were fueled, emboldened, enabled and inspired by a blog name Retraction Watch, the true instigator of Carlo Croce’s downfall and, specifically, of the NYT defamation piece.

Retraction Watch purportedly reports on scientific misconduct. Yet Retraction Watch is engaged in the most corrupt and less transparent scheme imaginable. To generate enough activity, the Retraction Watch founders created two anonymous characters, giving them writers’ names: Clare Francis and Fernando Pessoa. Clare Francis operates in secrecy, while Fernando Pessoa operates in the open. Unchecked allegations, including all kinds of inanities, personal attacks, etc. are first received by Ivan Oransky and Adam Marcus, the two medicine/science dropouts who founded Retraction Watch. Then, Oransky and his pal make sure these allegations turn into substantial news that can be reported by Retraction Watch. Soon after the unchecked allegations emanating from any source (literally any) land on Oransky’s desk, they get funneled by Clare Francis in the most brazen threatening terms imaginable to journals, institutions and individuals, that get harassed and coerced into taking immediate action. According to the journal editors, over 90% of the allegations by Clare Francis are simply gibberish. Once some scathing reaction, for example a journal retraction, is elicited by Clare Francis and gets out in the open, Retraction Watch immediately reports it, broadcasting the scathing news in the harshest terms possible. Retraction Watch can do this extremely swiftly, usually the very same day the reaction becomes public, obviously because Clare Francis is the secret arm of Retraction Watch: they generate the same news they broadcast. Immediately after Retraction Watch publishes their piece, Fernando Pessoa comments profusely on it adding other instances of perceived misconduct allegedly committed by the person under attack. Obviously, Fernando Pessoa can also act so swiftly and thoroughly on each case simply because it is also part of Retraction Watch. To summarize, first the secret arm Clare Francis elicits reactions by journals, institutions and individuals that are brazenly approached with misconduct accusations, then Retraction Watch openly scorns and humiliates the accused person in the harshest terms possible, and finally Fernando Pessoa adds as much salt to the injury as possible. That is how the coward defamation scheme works, as anyone with a moderate ability to think can figure out by reading Retraction Watch.

Let us now focus on Retraction Watch chasing and pillorying of Carlo Croce and on its inspirational enabling role in the NYT investigation. One of the most striking details of the NYT article is its identification by Glanz and Armendariz of Clare Francis, the secret arm of Retraction Watch, as the agent who brashly brought up thirty or more misconduct allegations against Carlo Croce to the attention of OSU authorities. It should be noted that Croce had been profusely attacked and defamed by Retraction Watch prior to the appearance of the NYT article, on May 5, 2014, on April 6, 2015, on October 10, 2016 and, especially, on January 24, 2017, when Fernando Pessoa, the second arm of Retraction Watch, added 15 (fifteen) scathing comments against Carlo Croce on the very same day! In this way, all of Clare Francis accusations presented to OSU were fully covered also by Retraction Watch. On March 8, 2017, within a few hours after the NYT article came out, Retraction Watch published its own fiercely scathing article against Carlo Croce, covering the NYT defamation in gory detail and even amplifying the damage, and this time Fernando Pessoa added 13 (thirteen) comments describing more instances of misconduct allegedly committed by Carlo Croce. On March 15, another article damaging Carlo Croce came out at Retraction Watch, but the apotheosis came on March 30, 2017, a day after the AACR prize to Carlo Croce was announced. Oransky and his pal were truly incensed. On March 30, 2017 in an article entitled “Cancer org bestows award on scientist under investigation“, Retraction Watch expressed its outrage that Carlo Croce, a person seriously suspected of misconduct, would be given a prize by a “Cancer org” (Retraction Watch was referring to the American Association of Cancer Research). Fernando Pessoa swiftly added three scathing comments that day. Retraction Watch kept of defaming Croce on April 3, 2017 (Fernando Pessoa added 9 nasty comments this time), June 9, August 29, and September 8, 2017, with Fernando Pessoa adding scathing comments each time.

Carlo Croce sued the NYT for defamation. He should not spare Retraction Watch, the instigator and enabler of the NYT article. Oransky and his pal Marcus should be served in court for the great disservice they are doing to science and to the people whose lives are saved every day thanks to Croce’s discoveries.

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Ariel Fernandez, Ariel Fernandez Publications, Ariel Fernandez Stigliano, Bert Vogelstein, Cancer Cure, Cancer Research, Immunotherapy, Keytruda (pembrolizumab), Lynch syndrome, Mismatch Repair Deficiency

Cancer Cure Within Reach: Our Gratitude to Ariel Fernandez and Especially to Bert Vogelstein

 

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Bert Vogelstein and Ariel Fernandez (aged 69 and 60, respectively).

The immune checkpoint blocker pembrolizumab (Keytruda, Merck) has proven most successful to treat solid tumors harboring a DNA mismatch repair (MMR) deficiency.  This striking result recently reported by Luis Diaz Jr., Bert Vogelstein and their collaborators was anticipated a couple of years before by Dr. Vogelstein, a towering figure in oncological research. Ariel Fernandez has now shown that it is possible to generate a drug-promoted phenotype mimicking the MMR deficiency in solid tumors and thereby engineer a generic hypersusceptibility to Keytruda. This sensitivity is achieved through drug-induced metabolic stress on DNA synthesis.

The striking results by Diaz, Vogelstein and coworkers prompted Ariel Fernandez to address the following question: Is it possible to induce the MMR deficiency in any solid tumor, for example through targeted drug-based therapy, and thereby enhance the cancer antigenic activity and diversity to turn the Keytruda-drug combination into a universal cure for cancer?

Presentation1

Ariel Fernandez, Trends in Cancer, 2017

As work at Ariel Fernandez Consultancy reveals, the answer to this question is a resounding yes. The key to the problem resides in identifying a signaling pathway that gets recruited to promote MMR and then identifying a kinase inhibitor that would block that pathway.  The MMR deficiency-inducing kinase inhibitor has been found at Ariel Fernandez Consultancy. The potential of such drug-Keytruda combinations as universal treatments for solid tumors deserves clinical evaluation. Collaborative work is underway at Ariel Fernandez Consultancy to validate this paradigm. This may well be a decisive step in cancer cure.

Related Reading

Ariel Fernandez: “Engineering Tumor Hypersusceptibility to Checkpoint Immunotherapy”, Trends in Cancer (2017) Published online September 4.

 

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Applied Mathematics, Ariel Fernandez, Ariel Fernandez book, Ariel Fernandez Stigliano, Book review, 阿列尔·费尔南德斯, Protein Biophysics, Ridgway Scott

Book Review on “A Mathematical Approach to Protein Biophysics” by Ridgway Scott and Ariel Fernandez: An Introduction to AF’s Solution to the Protein Folding Problem

A new book by Ridgway Scott and Ariel Fernandez is coming out. Its title “A Mathematical Approach to Protein Biophysics” (Springer, 2017) feels unusual at first. Why do we need a mathematical approach to understand proteins? Perhaps we need to be reminded that the major problems in molecular biophysics, such as the protein folding problem, have remained open because they demand a level of intellectual maturity that is not yet commonly found in the biological sciences and can be provided by applied math. And yet, few applied mathematicians have managed to say some relevant to biology partly because, rather than trying to find out how nature did it, they try to tell nature how to do it. Here I am referring specifically to the protein folding problem, whose first-principle solution was finally published by Ariel Fernandez in 2016 (Physics at the Biomolecular Interface, Chapter 3). When we think carefully about these monumental challenges, the need to engage mathematicians in the development of molecular biophysics hardly needs justification. The new book by Ridgway Scott and Ariel Fernandez fulfills the need admirably, serving as a mathematician’s introduction to protein biophysics.

 

The publication particulars are:

Title: A Mathematical Approach to Protein Biophysics

Authors: L. Ridgway Scott, Ariel Fernández

Publisher: Springer International Publishing AG, CH

Pages: 284

Year: 2017

Price: 69.99 US dollars

Hardcover ISBN: 978-3-319-66031-8

Series Title: Biological and Medical Physics, Biomedical Engineering

Topics: Mathematical and Computational Biology

 

 

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Corruption, Data Fabrication, Data Falsification, Joshua L. Cherry, Joshua L. Cherry NIH, Meta-Research, Misconduct, Post publication peer review, Post Publication Peer Review Scam, Research Integrity, Research misconduct, Science reproducibility, Science Transparency, Scientific corruption

Reproducibility crisis, sure, but the real crisis is who handles the crisis

The New York Times wants to make us aware there is a reproducibility crisis in science. This is hardly news at all. There surely is a problem and has been there ever since science began to be run like a business, with its system of gratification and punishment, with the explosion in the number of practitioners and the number and size of professional journals, the pressure to excel, the emphasis on quantifying the impact, the system of extramural funding, etc. Take any under-regulated activity, create a system of gratification and you have a problem. It is called human nature.

The real challenge for science today is who is handling the perceived crisis. The science establishment got caught off guard on this one. As it turns out, the ones now handling the crisis are precisely those who installed the perception that there is a crisis in the first place. These are, perhaps with a few exceptions, angry people, science drop-outs and losers who found that science is just too difficult for them. The real problem is that the perception of the crisis has created a void in science governance, i. e. who is going to deal with the problem. Nowadays we have journals of scientific integrity (incredibly boring), world meetings on scientific integrity, not to mention blogs, etc. These are fora designed to channel the voice of those engaged in this second-rate activity.

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Cancer Research, Carlo Croce, Character Assassination, Civil Death, Clare Francis, Data Fabrication, Data Falsification, Defamation, Defamation lawsuit, First Amendment to US Constitution, Fraud, Ivan Oransky, National Institutes of Health, New York Times, NIH, NIH funding, Office of Research Integrity, Ohio State University, Paul S. Thaler, protected free speech, Research misconduct, Retraction Watch, Scientific corruption, Scientific publication

Stellar cancer researcher Carlo Croce falls from grace: hypocrisy in science

Last week The New York Times published a front-page story entitled “Years of Ethics Charges but Star Cancer Researcher Gets a Pass“.  The article grossly disparages Prof. Carlo Croce, a towering figure in cancer biology and genetics, and his home institution, The Ohio State University. It describes in some detail multiple accusations of misconduct and malfeasance that have been targeting Croce for years.

bio_croce

Dr. Carlo M. Croce, Ohio State University

We are told that Croce has been dodging grave allegations that he falsified data in research supported by more than $86 million in federal grants that have been awarded to him. The investigative task of the Times reporters was greatly facilitated by the fact that the records at Ohio’s courthouses and its university system are completely open to the public. And Ohio State University, which claims it had spent more money supporting Dr. Croce’s research than it had received in grants, was apparently totally responsive to requests for records.

The big problem with all this is that to this day there is no hard evidence of misconduct implicating Croce. Ohio State had repeatedly investigated Croce and cleared him of wrongdoing every single time. How disinterested these investigations were is of course a matter of debate.

Since Dr. Carlo Croce has not been proven guilty of misconduct by the preponderance of evidence, the public does not have the right to know about these investigations and he must be presumed innocent. The integrity of Croce’s career should have been protected. The New York Times article is actionable in Court.

The most astonishing aspect of the story is that neither government agencies nor Ohio State believed Croce would be seriously investigated for misconduct, since he is one of Ohio State biggest rainmakers. This bespeaks of a system corrupt to the marrow and draws a lesson that epitomizes the level of hypocrisy that plagues the science establishment.

Of course we wonder who sent James Glanz, the Times reporter, the documents that appeared in Mr. Glanz’s email inbox, in what his collaborator Agustin Armendariz calls three big dumps. This is anyone’s guess. The Times story mentions Clare Francis, the pseudonym for an agent for the blog Retraction Watch, whose brash nauseating style is reminiscent of Ivan Oransky’s writing…

In any case, that would be discovered in Court if and when Dr. Carlo M. Croce decides to take legal action.

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Blog, Character Assassination, Clare Francis, Defamation, Defamation lawsuit, Expression of concern, Hilda Bastian, lawsuit, Mass hysteria, McCarthyism, National Institutes of Health, NCBI, NIH, NLM, Office of Research Integrity, Paul S. Thaler, Post publication peer review, Post Publication Peer Review Scam, Reporting Retractions, Research Integrity, Research misconduct, Retraction, Retraction Watch, Scientific corruption, Scientific Misconduct, Scientific publication, Scientific Reproducibility

Handling scientific post-publication events: Legal action required

Hilda Bastian is an NIH contractor for PubMed Health and PubMed Commons at the National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine (NLM). She also seems to be a prolific science writer. Bastian recently informed the blog Retraction Watch that the NLM is planning a prominent display of Expressions of Concern (EoC) published by scientific journals. By her own admission, Hilda Bastian is not versed in scientific matters. Given what she intends to do, let us hope she is versed in legal matters, or at least willing to seek legal advice.

In the US, as in most societies under the rule of law, a person is deemed innocent unless proven guilty, and any suggestion that may affect someone’s reputation without hard proof constitutes defamation. By Bastian’s own admission, only about 25% of EoCs typically result in retraction. This begs the question: What do the authors whose papers received the remaining 75% of EoCs plan to do?

Lawyer Paul S. Thaler, a towering figure in scientific integrity may be the ideal person to assist such people determine their legal options. Paul S. Thaler made the following enlightening remark:

The first thing to remember is that the federal regulations, as well as the internal policies of most institutions, protect the confidentiality of respondents in research misconduct matters.  Thus, as a matter of federal law, institutions are prohibited from disclosing the identity of an accused scientist, except on a “need to know” basis, for example, to a member of the investigation committee, unless and until a finding of research misconduct is made.  These proceedings are not public as court is in criminal and civil disputes.  It is more comparable to proceedings against other professionals, such as lawyers, who are governed by their licensing organization.  Privacy in these matters is critically important as there is no public need to, or right to know, about professionals simply accused of wrongdoing.  What the public has a right to know about is a professional who has been found responsible for wrongdoing.  At that point, the public is alerted.  But because a professional’s reputation is so important to his or her career, the specter of an accusation can permanently stain that reputation and frequently the accusation is not well founded.  So the confidentiality of the process allows a full examination before the public is made aware.  We certainly do want to know about those scientists who have actually done something wrong that impacts science, but we do not, and should not, be concerned with those who are good scientists but caught up in a sometimes very political, internal dispute.

The bold section is crucial because it implies that EoCs are in all likelihood illegal, and so is the dissemination of such statements. The public does not have the right to know about mere accusations of wrongdoing, or suspicions of invalid data resulting in EoCs. According to Hilda Bastian such EoCs are likely to be wrong in 75% of the cases. For example, pseudonymous Clare Francis, the venal whistle-blower of Retraction Watch, has scored plenty of false positives eliciting EoCs mostly in the 75% of valid papers. Yet we are not aware that Retraction Watch or other related venues have been sued yet. Hopefully, Hilda Bastian will reflect about her plans and seek legal advice before charging ahead.

 

 

 

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Adam Marcus, Anonymous Peer Review, Blog, Character Assassination, Civil Death, Clare Francis, Defamation, Defamation lawsuit, Donald Trump, Expression of concern, Ivan Oransky, John Ioannidis, Joshua Cherry, Joshua L. Cherry, Joshua L. Cherry NIH, Post publication peer review, Post Publication Peer Review Scam, Reporting Retractions, Research Integrity, Retraction Watch, Science, Science blogs, Science Journalism, Science Transparency, Scientific corruption, US President

Anonymous peer review is fine, while anonymous post-publication review is not

When a scientist submits a paper for publication to a journal, he entrusts the journal editor with the task of finding peers would be able to review the paper and are knowledgeable enough to assess its scientific merit. The names of the reviewers are typically concealed to the author. The intent is to grant the reviewer complete freedom in his candid assessment without fear of retaliation. The system is imperfect, very much so, but during the last three centuries scientists have not managed to come up with anything better.

Post-publication peer review (PPPR), on the other hand, cannot be said to be imperfect. It is not even wrong. It is a grotesque aberration. PPPR is usually anonymous but in this case we have absolutely no assurance that the reviewer of the paper is a peer of the author, that is, someone capable of passing serious judgment, or rather someone with an ax to grind launching his or her personal attack. There is simply no editor that arbitrates PPPR, just reporters or science outsiders, like Ivan Oransky, who typically know nothing of the scientific subject of the paper and who merely reproduce a note in a journal or a piece of gossip or an opinion without adding any value. The consequences of this lack of leadership are dire for science: about 90% of the attacks launched by Oransky’s blog Retraction Watch under the pseudonym Clare Francis are either false or lacking merit, even if they manage to elicit an “expression of concern” (an illegality stigmatizing a person presumed innocent unless proven guilty). If US president Donald Trump branded reporters as a pathetic dishonest bunch, just imagine what he would have to say about blogs like Retraction Watch, where the founding reporters usually know nothing about the science related to their mini-scandals.

 

Oransky

This atmosphere of dishonesty provides a fertile soil for PPPR, where a few snipers like Joshua L. Cherry (NIH/NCBI?) strive. As readers may recall, Joshua L. Cherry has been identified by Science Transparency. Cherry is truly obsessed (read Cherry’s exchange with Prof. John Ioannidis), but unfortunately not with producing good science. When he launches personal attacks, Cherry disguises under multiple pseudonyms and e-mails, he cowardly shoots from the shadows, yet his style remains unmistakable: He obsessively insists in performing statistical analysis of large datasets with no scientific understanding of the data, or obsessively tries to reproduce data in a field he knows nothing about, failing miserably. Unfortunately, Joshua L. Cherry is the kind of byproduct that Retraction Watch and other such blogs generate. Were it not for the lack of leadership in PPPR, Cherry would have probably remained a scientist perhaps not incapable of generating interesting ideas. Yet, like many at Retraction Watch, he got trapped in futile battles against windmills.

As the Romans used to say: video meliora proboque, deteriora sequor ( I see the best and verify it, but I follow the worst). Tragic, tragic…

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